Title
Iron (III) hydroxiphosphate nanoparticles: preparation, physicochemical
characterization and potential use as vaccine adjuvants
characterization and potential use as vaccine adjuvants
Poster
Description
Nadezhda Angelova, Georgi Yordanov
Faculty of Chemistry and Pharmacy, University of Sofia ‘‘St. Kliment Ohridski”
Faculty of Chemistry and Pharmacy, University of Sofia ‘‘St. Kliment Ohridski”
Subject
Vaccine adjuvants are compounds that in combination with antigens potentiate their
immunogenicity and play key role for the efficiency of inactivated vaccines. Widely used
adjuvants in routine human vaccinations are aluminium(III) oxyhydroxide and
hydroxyphosphate. Although aluminum compounds are used as adjuvants for human
vaccines for many years owing to their good track record of safety, low cost, and
adjuvanticity with a variety of antigens, these adjuvants have certain limitations
(ineffective induction of Th1 type cytotoxic immune response, selective induction of Th2
type immune response, low efficacy for some antigens, stimulation of eosinophilia,
production of specific and total IgE antibodies, etc.) These limitations are the major
motivation for the search of alternative adjuvants with improved efficacy and safety.
Here, we provide synthesis and physicochemical characterisation of nanostructured iron
(III) hydroxyphosphate as a potential alternative to aluminium hydroxyphosphate vaccine
adjuvants. In favour of our study is the well known fact that ferric-based adjuvants have a
more balanced Th1–Th2 profile compare to aluminium adjuvants. The obtained materials
were characterized for elemental composition, crystalstructure, isoelectric points, protein
adsorption, and dissolution rate in sodium citrate solution, which are important
physicochemical characteristics to be studied in the early adjuvant development stages
immunogenicity and play key role for the efficiency of inactivated vaccines. Widely used
adjuvants in routine human vaccinations are aluminium(III) oxyhydroxide and
hydroxyphosphate. Although aluminum compounds are used as adjuvants for human
vaccines for many years owing to their good track record of safety, low cost, and
adjuvanticity with a variety of antigens, these adjuvants have certain limitations
(ineffective induction of Th1 type cytotoxic immune response, selective induction of Th2
type immune response, low efficacy for some antigens, stimulation of eosinophilia,
production of specific and total IgE antibodies, etc.) These limitations are the major
motivation for the search of alternative adjuvants with improved efficacy and safety.
Here, we provide synthesis and physicochemical characterisation of nanostructured iron
(III) hydroxyphosphate as a potential alternative to aluminium hydroxyphosphate vaccine
adjuvants. In favour of our study is the well known fact that ferric-based adjuvants have a
more balanced Th1–Th2 profile compare to aluminium adjuvants. The obtained materials
were characterized for elemental composition, crystalstructure, isoelectric points, protein
adsorption, and dissolution rate in sodium citrate solution, which are important
physicochemical characteristics to be studied in the early adjuvant development stages