Title
Kinetic Modeling on Drug Release
Poster
Description
Georgi Maslenski, Ivan Parapunov, Christo Tzatchev
Faculty of Chemistry and Pharmacy, University of Sofia ‘‘St. Kliment Ohridski”
Faculty of Chemistry and Pharmacy, University of Sofia ‘‘St. Kliment Ohridski”
Subject
Over the past 100 years, drug delivery systems have made tremendous progress in their
efficacy and effectiveness. Thus, a simple tablet becomes a complex system providing
controlled release. Initial drug delivery systems were characterized by an immediate and
uncontrollable release kinetics, therefore drug absorption was controlled only by the
ability of the body to assimilate the therapeutic molecule. This way the drug concentration
in different body tissuestypically undergo a sharp increase followed by a similar decrease.
As a result, toxic or ineffective therapeutic drug concentrations can be reached. Various
kinetic drug release models are used to achieve constant levels of drug concentration in
the blood or target tissues over defined periods of time. This is achieved by controlling the
rate and duration of drug release. Kinetic drug release models are an inevitable tool for
discovering modern therapies to increase drug efficacy and patient compliance, also
reducing the frequency and severity of adverse drug reactions.
efficacy and effectiveness. Thus, a simple tablet becomes a complex system providing
controlled release. Initial drug delivery systems were characterized by an immediate and
uncontrollable release kinetics, therefore drug absorption was controlled only by the
ability of the body to assimilate the therapeutic molecule. This way the drug concentration
in different body tissuestypically undergo a sharp increase followed by a similar decrease.
As a result, toxic or ineffective therapeutic drug concentrations can be reached. Various
kinetic drug release models are used to achieve constant levels of drug concentration in
the blood or target tissues over defined periods of time. This is achieved by controlling the
rate and duration of drug release. Kinetic drug release models are an inevitable tool for
discovering modern therapies to increase drug efficacy and patient compliance, also
reducing the frequency and severity of adverse drug reactions.