Тhe molecular mechanism of intestinal calcium transport

Title

Poster

Description

Dayana Ivanova1, Ivon Decheva1, Katarina Arsov1, Desislava Abadjieva2
1Biological Faculty, Sofia University "St. Kliment Ohridski ", Bulgaria
2Institute of Biology and Immunology of Reproduction "Acad. Kiril Bratanov", Bulgarian Academy of Sciences, Sofia, Bulgaria

Subject

Intestinal calcium absorption is a complex process dependent on several factors, of which 1.25 (OH) 2D3 is the major control hormone. The effectiveness of calcium absorption is a function of calcium status and need. As the demand for calcium of the body increases, the process, commonly called adaptation, is activated, which increases the synthesis of 1,25 (OH) 2 D3 from the precursor, which leads to stimulation of the absorption rate of calcium. Increased calcium demand may be due to ingestion of a calcium-free diet, growth, pregnancy, breastfeeding and eggshell formation. Along with the change in calcium absorption efficiency, there are molecular modifications of transporting enterocytes. Highly correlated to the rate of calcium absorption under a wide variety of conditions is the concentration of calcium-binding protein induced by vitamin D, calbindin-D28K (bird type) and calbindin-D9K (intestinal type of mammal). The role of calbindin in this transport process is not well known, but is currently thought to act as a cytosolic calcium channel diffuser from the brush border membrane to the basal lateral membrane. The growing interest in dietary plants today due to the high content of bioactive substances (polyphenols), for example artichoke, has pharmacological and biochemical effects, with antioxidant potential and calcium-prophylactic properties. Therefore, there is considerable interest in improving the understanding of the effect of additives such as artichokes on the molecular mechanisms of calcium transport, which may result in the development of nutritional and medical strategies to optimize calcium absorption efficiency and prevent pathologies associated with metabolism of calcium.
Key words: Calcium, Calbindin, Absorption