Evaluation of lipid nanoparticles as promising drug carriers

Evaluation of lipid nanoparticles as promising drug carriers

Poster

Kostadin Terziev, Christo Tzachev 
Faculty of Chemistry and Pharmacy, University of Sofia ‘‘St. Kliment Ohridski”

Lipid nanoparticles (LN) are particles with size varying from 50 to 1000 nm, they can be described as nanoemulsion oil-in-water in which the liquid lipid phase is replaced by solid one. They were first introduced in the early 1990s as promising alternative drug carrier system to emulsions, liposomes, polymeric nanoparticles and traditional dosage forms. The deep interest in LN is predetermined by their intrinsic properties – they are non-toxic, comprise mostly pharmacopoeia-listed (USP, Ph.Eur.) excipients and can successfully resolve different biopharmaceutical and technological problems (e.g. low solubility, low chemical stability of the active pharmaceutical ingredients (APIs), low bioavailability, drug targeting etc.).