Clinical trials as opportunity for patients with low response to conventional therapies: bulgarian patients` perspective

Clinical trials as opportunity for patients with low response to conventional therapies: bulgarian patients` perspective

Poster

Tsvetelina Stefanova1, Evgeni Grigorov2;
1Hospital pharmacy, University hospital "St. Marina"-Varna, Bulgaria
2Department "Organization and economics of pharmacy", Faculty of Pharmacy, Medical University "Prof.Dr.Paraskev Stoyanov", Varna, Bulgaria

Introduction: Providing quality management of disease may not always be accomplishable with standard lines of treatment. In consideration for therapeutic opportunities MDs consider clinical trials a reasonable alternative for patients. Aim: The aim of this research is to point clinical trials as modern way to overcome the difficulty of achieving therapeutic result with patient who went through all researched lines of treatment of certain disease and to scope opportunities for enrolling in CTs in Bulgaria. Materials and methods: Information review of data is held using search engines PubMed, ScienceDirect, Springer, Scopus, and GoogleScholar. Possibility of patients being included in CTs is calculated using official data on registered trials and sites in Bulgaria. Results: The treatment of patients who show low response to standard lines of therapy is challenging and in search of proper alternatives MDs consider including those patients in CTs a reasonable option. According to published data for the period 2008-2022, Bulgaria is of the counties in Europe with high number of registered CTs. Analysis of the data shows concentration of registered sites in Sofia, Varna, Plovdiv, Pleven, Ruse, Burgas, Blagoevgrad. This disproportion of clinical sites sets different therapeutic approach for practitioners across the country making big cities a better alternative for receiving medical care for patients. Discussion: Including patients with low response to standard lines of therapy in CTs give chances for better health. Patients in Bulgaria have better chances for therapy as part of CTs shows analyzed data.
Keywords: Bulgaria, effect, medicines, clinical trials, therapeutic alternative