Analysis of medicines containing ibuprofen - release profiles

Analysis of medicines containing ibuprofen - release profiles

Oral presentation

Nikolay Daskalov, Iskra Koleva, Christo Tzachev
Faculty of Chemistry and Pharmacy, Sofia University "St. Kliment Ohridski ”, Bulgaria

Introduction: Ibuprofen is one of the most commonly used non-steroidal anti-inflammatory drugs. Being a reversible non-selective inhibitor of cyclooxygenase enzymes, it has an analgesic and antipyretic action due to the inhibition of prostaglandin synthesis. This is the reason for authors' interest in analyzing the release profiles of the active substance from several commercial products. Materials and methods: A pharmacopoeial dissolution test was conducted with 400mg film-coated tablets and oral suspensions containing 20mg / ml ibuprofen. The test was performed according to the USP methodology, namely pH 7.2 phosphate buffer, Apparatus 2 at 50 rpm, 70 min analysis time. The dissolved quantity was monitored by UV spectroscopy at 221nm and calibration curve which covers the results of the tests. Results: The results of the release tests are presented in tabular and graphical form, allowing the kinetics of release to be determined. The results are presented as a cumulative amount of ibuprofen released per unit time. Differences in release kinetics are demonstrated between the different dosage forms and a particular design aimed at optimizing the effect for the patient. The dissolution test makes it possible to find in vitro - in vivo correlation. Other studies have been conducted to characterize the dosage forms. Conclusion: The dissolution test showed the expected results against the pharmacopoeial requirements for all medicinal products. The effect of particle size on the dissolution rate of ibuprofen suspension was studied.
Keywords: dissolution test, kinetics of release, analytical testing